CovidFranceV1, Main, Exploration, bibRecord, 000515

Targeting potential drivers of COVID-19: Neutrophil extracellular traps.

Identifieur interne : 000515 ( Main/Exploration ); précédent : 000514; suivant : 000516

Targeting potential drivers of COVID-19: Neutrophil extracellular traps.

Auteurs : Betsy J. Barnes [États-Unis] ; Jose M. Adrover [États-Unis] ; Amelia Baxter-Stoltzfus [États-Unis] ; Alain Borczuk [États-Unis] ; Jonathan Cools-Lartigue [Canada] ; James M. Crawford [États-Unis] ; Juliane Da Ler-Plenker [États-Unis] ; Philippe Guerci [France] ; Caroline Huynh [Canada] ; Jason S. Knight [États-Unis] ; Massimo Loda [États-Unis] ; Mark R. Looney [États-Unis] ; Florencia Mcallister [États-Unis] ; Roni Rayes [Canada] ; Stephane Renaud [France] ; Simon Rousseau [Canada] ; Steven Salvatore [États-Unis] ; Robert E. Schwartz [États-Unis] ; Jonathan D. Spicer [Canada] ; Christian C. Yost [États-Unis] ; Andrew Weber [États-Unis] ; Yu Zuo [États-Unis] ; Mikala Egeblad [États-Unis]

Source :

The Journal of experimental medicine [ 1540-9538 ] ; 2020.

RBID : pubmed:32302401

Descripteurs français

KwdFr :
- Betacoronavirus (MeSH), Cytokines (métabolisme), Granulocytes neutrophiles (anatomopathologie), Humains (MeSH), Infections à coronavirus (anatomopathologie), Infections à coronavirus (complications), Maladies pulmonaires (anatomopathologie), Maladies pulmonaires (métabolisme), Maladies pulmonaires (étiologie), Pandémies (MeSH), Pièges extracellulaires (MeSH), Pneumopathie virale (anatomopathologie), Pneumopathie virale (complications).
MESH :
- anatomopathologie : Granulocytes neutrophiles, Infections à coronavirus, Maladies pulmonaires, Pneumopathie virale.
- métabolisme : Cytokines, Infections à coronavirus, Maladies pulmonaires, Pneumopathie virale.
- étiologie : Maladies pulmonaires.
- Betacoronavirus, Humains, Pandémies, Pièges extracellulaires.

English descriptors

KwdEn :
- Betacoronavirus (MeSH), Coronavirus Infections (complications), Coronavirus Infections (pathology), Cytokines (metabolism), Extracellular Traps (MeSH), Humans (MeSH), Lung Diseases (etiology), Lung Diseases (metabolism), Lung Diseases (pathology), Neutrophils (pathology), Pandemics (MeSH), Pneumonia, Viral (complications), Pneumonia, Viral (pathology).
MESH :
- chemical , metabolism : Cytokines.
- complications : Coronavirus Infections, Pneumonia, Viral.
- etiology : Lung Diseases.
- metabolism : Lung Diseases.
- pathology : Coronavirus Infections, Lung Diseases, Neutrophils, Pneumonia, Viral.
- Betacoronavirus, Extracellular Traps, Humans, Pandemics.

Abstract

Coronavirus disease 2019 (COVID-19) is a novel, viral-induced respiratory disease that in ∼10-15% of patients progresses to acute respiratory distress syndrome (ARDS) triggered by a cytokine storm. In this Perspective, autopsy results and literature are presented supporting the hypothesis that a little known yet powerful function of neutrophils-the ability to form neutrophil extracellular traps (NETs)-may contribute to organ damage and mortality in COVID-19. We show lung infiltration of neutrophils in an autopsy specimen from a patient who succumbed to COVID-19. We discuss prior reports linking aberrant NET formation to pulmonary diseases, thrombosis, mucous secretions in the airways, and cytokine production. If our hypothesis is correct, targeting NETs directly and/or indirectly with existing drugs may reduce the clinical severity of COVID-19.

DOI: 10.1084/jem.20200652
PubMed: 32302401
PubMed Central: PMC7161085

Affiliations:

Canada, France, États-Unis
Californie, Grand Est, Lorraine (région), Michigan, Québec, Texas, Utah, État de New York
Montréal, Nancy
Université McGill

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 001699
to stream Main, to step Curation: 001699

Le document en format XML

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<author><name sortKey="Guerci, Philippe" sort="Guerci, Philippe" uniqKey="Guerci P" first="Philippe" last="Guerci">Philippe Guerci</name>
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</placeName>
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<author><name sortKey="Looney, Mark R" sort="Looney, Mark R" uniqKey="Looney M" first="Mark R" last="Looney">Mark R. Looney</name>
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</placeName>
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<author><name sortKey="Renaud, Stephane" sort="Renaud, Stephane" uniqKey="Renaud S" first="Stephane" last="Renaud">Stephane Renaud</name>
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<author><name sortKey="Rousseau, Simon" sort="Rousseau, Simon" uniqKey="Rousseau S" first="Simon" last="Rousseau">Simon Rousseau</name>
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</placeName>
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<author><name sortKey="Spicer, Jonathan D" sort="Spicer, Jonathan D" uniqKey="Spicer J" first="Jonathan D" last="Spicer">Jonathan D. Spicer</name>
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<author><name sortKey="Yost, Christian C" sort="Yost, Christian C" uniqKey="Yost C" first="Christian C" last="Yost">Christian C. Yost</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Utah</region>
</placeName>
<wicri:cityArea>Department of Pediatrics, Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Weber, Andrew" sort="Weber, Andrew" uniqKey="Weber A" first="Andrew" last="Weber">Andrew Weber</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Northwell Health, Manhasset, NY.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Northwell Health, Manhasset</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Zuo, Yu" sort="Zuo, Yu" uniqKey="Zuo Y" first="Yu" last="Zuo">Yu Zuo</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Egeblad, Mikala" sort="Egeblad, Mikala" uniqKey="Egeblad M" first="Mikala" last="Egeblad">Mikala Egeblad</name>
<affiliation wicri:level="2"><nlm:affiliation>Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Cold Spring Harbor Laboratory, Cold Spring Harbor</wicri:cityArea>
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<date when="2020">2020</date>
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</affiliation>
</author>
<author><name sortKey="Adrover, Jose M" sort="Adrover, Jose M" uniqKey="Adrover J" first="Jose M" last="Adrover">Jose M. Adrover</name>
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<placeName><region type="state">État de New York</region>
</placeName>
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</affiliation>
</author>
<author><name sortKey="Baxter Stoltzfus, Amelia" sort="Baxter Stoltzfus, Amelia" uniqKey="Baxter Stoltzfus A" first="Amelia" last="Baxter-Stoltzfus">Amelia Baxter-Stoltzfus</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Borczuk, Alain" sort="Borczuk, Alain" uniqKey="Borczuk A" first="Alain" last="Borczuk">Alain Borczuk</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York</wicri:cityArea>
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<author><name sortKey="Cools Lartigue, Jonathan" sort="Cools Lartigue, Jonathan" uniqKey="Cools Lartigue J" first="Jonathan" last="Cools-Lartigue">Jonathan Cools-Lartigue</name>
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<country xml:lang="fr">Canada</country>
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<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Crawford, James M" sort="Crawford, James M" uniqKey="Crawford J" first="James M" last="Crawford">James M. Crawford</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, East Garden City, NY.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, East Garden City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Da Ler Plenker, Juliane" sort="Da Ler Plenker, Juliane" uniqKey="Da Ler Plenker J" first="Juliane" last="Da Ler-Plenker">Juliane Da Ler-Plenker</name>
<affiliation wicri:level="2"><nlm:affiliation>Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Cold Spring Harbor Laboratory, Cold Spring Harbor</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Guerci, Philippe" sort="Guerci, Philippe" uniqKey="Guerci P" first="Philippe" last="Guerci">Philippe Guerci</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Hospitalier Universitaire de Nancy, Nancy, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Hospitalier Universitaire de Nancy, Nancy</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Lorraine (région)</region>
<settlement type="city">Nancy</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huynh, Caroline" sort="Huynh, Caroline" uniqKey="Huynh C" first="Caroline" last="Huynh">Caroline Huynh</name>
<affiliation wicri:level="3"><nlm:affiliation>Division of Thoracic and Upper GI Surgery, Department of Surgery, Montreal, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Thoracic and Upper GI Surgery, Department of Surgery, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Goodman Cancer Research Centre, McGill University, Montreal, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Goodman Cancer Research Centre, McGill University, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
<orgName type="university">Université McGill</orgName>
</affiliation>
</author>
<author><name sortKey="Knight, Jason S" sort="Knight, Jason S" uniqKey="Knight J" first="Jason S" last="Knight">Jason S. Knight</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Loda, Massimo" sort="Loda, Massimo" uniqKey="Loda M" first="Massimo" last="Loda">Massimo Loda</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Looney, Mark R" sort="Looney, Mark R" uniqKey="Looney M" first="Mark R" last="Looney">Mark R. Looney</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, University of California, San Francisco, San Francisco, CA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of California, San Francisco, San Francisco</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mcallister, Florencia" sort="Mcallister, Florencia" uniqKey="Mcallister F" first="Florencia" last="Mcallister">Florencia Mcallister</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Clinical Cancer Prevention, University of Texas MD Anderson Cancer Center, Houston, TX.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Clinical Cancer Prevention, University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rayes, Roni" sort="Rayes, Roni" uniqKey="Rayes R" first="Roni" last="Rayes">Roni Rayes</name>
<affiliation wicri:level="3"><nlm:affiliation>Division of Thoracic and Upper GI Surgery, Department of Surgery, Montreal, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Thoracic and Upper GI Surgery, Department of Surgery, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Goodman Cancer Research Centre, McGill University, Montreal, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Goodman Cancer Research Centre, McGill University, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
<orgName type="university">Université McGill</orgName>
</affiliation>
</author>
<author><name sortKey="Renaud, Stephane" sort="Renaud, Stephane" uniqKey="Renaud S" first="Stephane" last="Renaud">Stephane Renaud</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Hospitalier Universitaire de Nancy, Nancy, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Hospitalier Universitaire de Nancy, Nancy</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Lorraine (région)</region>
<settlement type="city">Nancy</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rousseau, Simon" sort="Rousseau, Simon" uniqKey="Rousseau S" first="Simon" last="Rousseau">Simon Rousseau</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Medicine, McGill University & The Research Institute of the McGill University Health Centre, Montreal, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medicine, McGill University & The Research Institute of the McGill University Health Centre, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Salvatore, Steven" sort="Salvatore, Steven" uniqKey="Salvatore S" first="Steven" last="Salvatore">Steven Salvatore</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Schwartz, Robert E" sort="Schwartz, Robert E" uniqKey="Schwartz R" first="Robert E" last="Schwartz">Robert E. Schwartz</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, NY.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Spicer, Jonathan D" sort="Spicer, Jonathan D" uniqKey="Spicer J" first="Jonathan D" last="Spicer">Jonathan D. Spicer</name>
<affiliation wicri:level="3"><nlm:affiliation>Division of Thoracic and Upper GI Surgery, Department of Surgery, Montreal, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Thoracic and Upper GI Surgery, Department of Surgery, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Goodman Cancer Research Centre, McGill University, Montreal, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Goodman Cancer Research Centre, McGill University, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
<orgName type="university">Université McGill</orgName>
</affiliation>
</author>
<author><name sortKey="Yost, Christian C" sort="Yost, Christian C" uniqKey="Yost C" first="Christian C" last="Yost">Christian C. Yost</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, UT.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Utah</region>
</placeName>
<wicri:cityArea>Department of Pediatrics, Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Weber, Andrew" sort="Weber, Andrew" uniqKey="Weber A" first="Andrew" last="Weber">Andrew Weber</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Northwell Health, Manhasset, NY.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Northwell Health, Manhasset</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Zuo, Yu" sort="Zuo, Yu" uniqKey="Zuo Y" first="Yu" last="Zuo">Yu Zuo</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Egeblad, Mikala" sort="Egeblad, Mikala" uniqKey="Egeblad M" first="Mikala" last="Egeblad">Mikala Egeblad</name>
<affiliation wicri:level="2"><nlm:affiliation>Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Cold Spring Harbor Laboratory, Cold Spring Harbor</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of experimental medicine</title>
<idno type="eISSN">1540-9538</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Betacoronavirus (MeSH)</term>
<term>Coronavirus Infections (complications)</term>
<term>Coronavirus Infections (pathology)</term>
<term>Cytokines (metabolism)</term>
<term>Extracellular Traps (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Lung Diseases (etiology)</term>
<term>Lung Diseases (metabolism)</term>
<term>Lung Diseases (pathology)</term>
<term>Neutrophils (pathology)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (complications)</term>
<term>Pneumonia, Viral (pathology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Betacoronavirus (MeSH)</term>
<term>Cytokines (métabolisme)</term>
<term>Granulocytes neutrophiles (anatomopathologie)</term>
<term>Humains (MeSH)</term>
<term>Infections à coronavirus (anatomopathologie)</term>
<term>Infections à coronavirus (complications)</term>
<term>Maladies pulmonaires (anatomopathologie)</term>
<term>Maladies pulmonaires (métabolisme)</term>
<term>Maladies pulmonaires (étiologie)</term>
<term>Pandémies (MeSH)</term>
<term>Pièges extracellulaires (MeSH)</term>
<term>Pneumopathie virale (anatomopathologie)</term>
<term>Pneumopathie virale (complications)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Granulocytes neutrophiles</term>
<term>Infections à coronavirus</term>
<term>Maladies pulmonaires</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lung Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lung Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytokines</term>
<term>Infections à coronavirus</term>
<term>Maladies pulmonaires</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Lung Diseases</term>
<term>Neutrophils</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Maladies pulmonaires</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Betacoronavirus</term>
<term>Extracellular Traps</term>
<term>Humans</term>
<term>Pandemics</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Betacoronavirus</term>
<term>Humains</term>
<term>Pandémies</term>
<term>Pièges extracellulaires</term>
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<front><div type="abstract" xml:lang="en">Coronavirus disease 2019 (COVID-19) is a novel, viral-induced respiratory disease that in ∼10-15% of patients progresses to acute respiratory distress syndrome (ARDS) triggered by a cytokine storm. In this Perspective, autopsy results and literature are presented supporting the hypothesis that a little known yet powerful function of neutrophils-the ability to form neutrophil extracellular traps (NETs)-may contribute to organ damage and mortality in COVID-19. We show lung infiltration of neutrophils in an autopsy specimen from a patient who succumbed to COVID-19. We discuss prior reports linking aberrant NET formation to pulmonary diseases, thrombosis, mucous secretions in the airways, and cytokine production. If our hypothesis is correct, targeting NETs directly and/or indirectly with existing drugs may reduce the clinical severity of COVID-19.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32302401</PMID>
<DateCompleted><Year>2020</Year>
<Month>04</Month>
<Day>23</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>06</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1540-9538</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>217</Volume>
<Issue>6</Issue>
<PubDate><Year>2020</Year>
<Month>06</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>The Journal of experimental medicine</Title>
<ISOAbbreviation>J. Exp. Med.</ISOAbbreviation>
</Journal>
<ArticleTitle>Targeting potential drivers of COVID-19: Neutrophil extracellular traps.</ArticleTitle>
<ELocationID EIdType="pii" ValidYN="Y">e20200652</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1084/jem.20200652</ELocationID>
<Abstract><AbstractText>Coronavirus disease 2019 (COVID-19) is a novel, viral-induced respiratory disease that in ∼10-15% of patients progresses to acute respiratory distress syndrome (ARDS) triggered by a cytokine storm. In this Perspective, autopsy results and literature are presented supporting the hypothesis that a little known yet powerful function of neutrophils-the ability to form neutrophil extracellular traps (NETs)-may contribute to organ damage and mortality in COVID-19. We show lung infiltration of neutrophils in an autopsy specimen from a patient who succumbed to COVID-19. We discuss prior reports linking aberrant NET formation to pulmonary diseases, thrombosis, mucous secretions in the airways, and cytokine production. If our hypothesis is correct, targeting NETs directly and/or indirectly with existing drugs may reduce the clinical severity of COVID-19.</AbstractText>
<CopyrightInformation>© 2020 Barnes et al.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Barnes</LastName>
<ForeName>Betsy J</ForeName>
<Initials>BJ</Initials>
<AffiliationInfo><Affiliation>Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, The Feinstein Institutes for Medical Research & Departments of Molecular Medicine and Pediatrics, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Adrover</LastName>
<ForeName>Jose M</ForeName>
<Initials>JM</Initials>
<AffiliationInfo><Affiliation>Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Baxter-Stoltzfus</LastName>
<ForeName>Amelia</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Borczuk</LastName>
<ForeName>Alain</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cools-Lartigue</LastName>
<ForeName>Jonathan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Division of Thoracic and Upper GI Surgery, Department of Surgery, Montreal, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Crawford</LastName>
<ForeName>James M</ForeName>
<Initials>JM</Initials>
<AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, East Garden City, NY.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Daßler-Plenker</LastName>
<ForeName>Juliane</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guerci</LastName>
<ForeName>Philippe</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Centre Hospitalier Universitaire de Nancy, Nancy, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huynh</LastName>
<ForeName>Caroline</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Division of Thoracic and Upper GI Surgery, Department of Surgery, Montreal, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Goodman Cancer Research Centre, McGill University, Montreal, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Knight</LastName>
<ForeName>Jason S</ForeName>
<Initials>JS</Initials>
<AffiliationInfo><Affiliation>Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Loda</LastName>
<ForeName>Massimo</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Looney</LastName>
<ForeName>Mark R</ForeName>
<Initials>MR</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, University of California, San Francisco, San Francisco, CA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McAllister</LastName>
<ForeName>Florencia</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Cancer Prevention, University of Texas MD Anderson Cancer Center, Houston, TX.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rayes</LastName>
<ForeName>Roni</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Division of Thoracic and Upper GI Surgery, Department of Surgery, Montreal, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Goodman Cancer Research Centre, McGill University, Montreal, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Renaud</LastName>
<ForeName>Stephane</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Centre Hospitalier Universitaire de Nancy, Nancy, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rousseau</LastName>
<ForeName>Simon</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, McGill University & The Research Institute of the McGill University Health Centre, Montreal, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Salvatore</LastName>
<ForeName>Steven</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schwartz</LastName>
<ForeName>Robert E</ForeName>
<Initials>RE</Initials>
<AffiliationInfo><Affiliation>Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, NY.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Spicer</LastName>
<ForeName>Jonathan D</ForeName>
<Initials>JD</Initials>
<AffiliationInfo><Affiliation>Division of Thoracic and Upper GI Surgery, Department of Surgery, Montreal, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Goodman Cancer Research Centre, McGill University, Montreal, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yost</LastName>
<ForeName>Christian C</ForeName>
<Initials>CC</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, UT.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Weber</LastName>
<ForeName>Andrew</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Northwell Health, Manhasset, NY.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zuo</LastName>
<ForeName>Yu</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Egeblad</LastName>
<ForeName>Mikala</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>P30 CA045508</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 HD093826</GrantID>
<Acronym>HD</Acronym>
<Agency>NICHD NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Exp Med</MedlineTA>
<NlmUniqueID>2985109R</NlmUniqueID>
<ISSNLinking>0022-1007</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016207">Cytokines</NameOfSubstance>
</Chemical>
</ChemicalList>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
<SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>J Exp Med. 2020 Sep 7;217(9):</RefSource>
<PMID Version="1">32678431</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="Y">Betacoronavirus</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D065206" MajorTopicYN="Y">Extracellular Traps</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008171" MajorTopicYN="Y">Lung Diseases</DescriptorName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009504" MajorTopicYN="N">Neutrophils</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<CoiStatement>Disclosures: M.R. Looney reported "other" from Neutrolis outside the submitted work. R.E. Schwartz is a Sponsored Advisory Board Member for Miromatrix Inc. J.D. Spicer reported personal fees from Bristol Myers Squibb, personal fees from Astra Zeneca, personal fees from Merck, personal fees from Trans-Hit Bio, and non-financial support from Astra Zeneca outside the submitted work. C.C. Yost reports a grant from PEEL Therapeutics, Inc. during the conduct of the study; in addition, C.C. Yost authors a US patent (patent no. 10,232,023 B2) held by the University of Utah for the use of NET-inhibitory peptides for "treatment of and prophylaxis against inflammatory disorders." PEEL Therapeutics, Inc. has exclusive licensing rights. M. Egeblad reported "other" from Santhera during the conduct of the study; and consulted for CytomX in 2019. No other disclosures were reported.</CoiStatement>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>04</Month>
<Day>07</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2020</Year>
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	Serveur d'exploration sur la COVID en France
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Serveur d'exploration sur la COVID en France

Targeting potential drivers of COVID-19: Neutrophil extracellular traps.

Targeting potential drivers of COVID-19: Neutrophil extracellular traps.

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